JSI staff regularly publish their research and results from work in peer-reviewed journals. This section provides a brief abstract with a link to the journal where you can read more and either download or order the article, depending on the journal.
A Report of At-Scale Distribution of Chlorhexidine Digluconate 7.1% Gel for Newborn Cord Care to 36,404 Newborns in Sokoto State, Nigeria: Initial Lessons Learned in PLoS ONE, 10(7) July 30, 2015 DOI: 10.1371/journal.pone.0134040
With an annual estimated 276,000 neonatal deaths, Nigeria has the second highest of any country in the world. Global progress in accelerating neonatal deaths is hinged to scaled-up interventions in Nigeria. Routine data of chlorhexidine digluconate 7.1% gel utilized by 36,404 newborns delivered by 36,370 mothers, was use to study lessons associated with at-scale distribution in Sokoto State, North West Nigeria.
Enhancements in the predictable availability and supply of chlorhexidine digluconate 7.1% gel to communities through better, evidence-based logistics management by the state public sector will most likely dramatically increase program scalability. Infections as a cause of mortality in babies delivered in home settings may be much higher than previously conceived. In tandem with high prevalence of stillborn deaths, delivery, interventions designed to increase mothers’ timely and regular use of quality antenatal care, and increased facility-based based delivery, need urgent attention. We call for accelerated investments in community health volunteer programs and the requisite community measurement systems to better track coverage. We also advocate for the development, refinement and use of routine community-based verbal autopsies to track newborn and maternal survival.
Authors: Nosakhare Orobaton , Dele Abegunde, Kamil Shoretire, Jumare Abdulazeez, Bolaji Fapohunda, Goli Lamiri, Abubakar Maishanu, Akeem Ganiyu, Eric Ndifon, Ringpon Gwamzhi, Matthew Osborne-Smith (2015)
Successful Proof of Concept of Family Planning and Immunization Integration in Liberia in Global Health: Science and Practice, June 2015, Volume 3, Issue 2.
Globally, unmet need for postpartum family planning remains high, while immunization services are among the most wide reaching and equitable interventions. Given overlapping time frames, integrating these services provides an opportunity to leverage existing health visits to offer women more comprehensive services. From March through November 2012, Liberia’s government, with support from the Maternal and Child Health Integrated Program (MCHIP), piloted an integrated family planning and immunization model at 10 health facilities in Bong and Lofa counties. Vaccinators provided mothers bringing infants for routine immunization with targeted family planning and immunization messages and same-day referrals to co-located family planning services.
In February 2013, we compared service statistics for family planning and immunization during the pilot against the previous year’s statistics. We also conducted in-depth interviews with service providers and other personnel and focus group discussions with clients. However, results suggest that introducing a simple model that is minimally disruptive to existing immunization service delivery can facilitate integration. The model is currently being scaled-up to other counties in Liberia, which could potentially contribute to increased postpartum contraceptive uptake, leading to longer birth intervals and improved health outcomes for children and mothers. By Chelsea M Coopera, JSI's Rebecca Fields, Corinne I Mazzeoc, Nyapu Taylord, Anne Pfitzera, Mary Momolue, Cuallau Jabbeh-Howee.
Factors influencing the use of magnesium sulphate in pre-eclampsia/eclampsia management in health facilities in Northern Nigeria: a mixed methods study in BMC Pregnancy & Childbirth, Volume 15
Eclampsia remains a major cause of perinatal and maternal morbidity and mortality worldwide. Researchers from the JSI-managed Targeted States High Impact Project (TSHIP) collected data from 80 health facilities in Northern Nigeria's Bauchi and Sokoto states to examine facilitators and barriers to the use of magnesium sulphate in the management of pre-eclampsia/eclampsia. Research methods and results are presented in the full article, available at BMC Pregnancy & Childbirth.
Authors: Olugbenga Oguntunde, Zulfiya Charyeva, Molly Cannon, William Sambisa, Nosakhare Orobaton, Ibrahim A Kabo, Kamil Shoretire, Saba’atu E Danladi, Nurudeen Lawal, and Habib Sadauki.
Marine protected areas and children’s dietary diversity in the Philippines in Population and Environment, Journal No. 11111
Fish living around the coral reefs in the Philippines provide livelihoods for more than a million local fishers and are an important source of protein for coastal communities. However, this rich resource is at risk from myriad threats, which consequently threaten human livelihoods, nutrition, and health. In this paper, we examine the degree to which marine protected areas (MPAs), which aim to conserve marine biodiversity, are associated with improved nutritional outcomes in children under age 5. This analysis, which uses data from the 2008 Philippines Demographic and Health Survey and MPA data from the Coastal Conservation and Education Fund, found a positive association between MPAs and children’s dietary diversity when the MPAs were located closer than 2 km to a child’s community. MPA characteristics such as age or type of management were not consistently associated with dietary diversity. These results suggest a positive association of proximity to MPAs with certain aspects of children’s diet.
Authors: Soumya Alva, Kiersten Johnson, Anila Jacob, Heather D’Agnes, Richard Mantovani, Thea Evans.
Institutionalizing early vaccination of newborns delivered at government health facilities: Experiences from India in International Journal of Medical Research and Review, Volume 3, Issue 5
Newborn vaccination is identified as a critical parameter for evaluating the overall performance of immunization programs with guidelines clearly advocating for administration of BCG, OPV zero dose and Hepatitis B birth dose to newborns. In spite of sustained improvement in full immunization coverage in India, coverage of newborn vaccines has remained traditionally low. The USAID-supported Maternal and Child Health Integrated Program (MCHIP), operational in India from 2009 – 2014 provided technical support to the Universal Immunization Program (UIP) at the national level and in the states of Jharkhand and Uttar Pradesh. During the project period, MCHIP undertook an assessment in 46 selected health facilities across 5 districts of the two states to study the implementation of the newborn vaccination program.
Key findings included a lack of knowledge among staff about the benefits of newborn vaccination, absence of written guidelines, unavailability of one vaccine compromising the administration of the remaining two and poor documentation practices. Following the assessment, technical support was provided to strengthen implementation at these selected facilities. The intervention produced favorable results with a progressive increase in coverage of not only BCG and OPV zero dose but also Hepatitis B birth dose which was introduced in the UIP during the course of the intervention.
Overall this intervention, which focused on operationalizing an already existing strategy, clearly indicated that the practice of vaccinating newborns delivered at health facilities is easily implementable and replicable, and that its sustainability should ensure improved coverage and protection against targeted vaccine-preventable diseases. Authors: G Taneja, VK Mentey, M Jain, KS Sagar, B Tripathi, Michael Favin, Robert Steinglass.
Strategies for Coordination of a Serosurvey in Parallel with an Immunization Coverage Survey in The American Society of Tropical Medicine and Hygiene, Volume 92 (6)
A community-based immunization coverage survey is the standard way to estimate effective vaccination delivery to a target population in a region. Accompanying serosurveys can provide objective measures of protective immunity against vaccine-preventable diseases but pose considerable challenges with respect to specimen collection and preservation and community compliance. Serosurveys were performed coupled to immunization coverage surveys in three administrative districts (woredas) in rural Ethiopia. Critical to the success of this effort were serosurvey equipment and supplies, team composition, and tight coordination with the coverage survey. Application of these techniques to future studies may foster more widespread use of serosurveys to derive more objective assessments of vaccine-derived seroprotection and monitor and compare the performance of immunization services in different districts of a country.
Authors: Mark A. Travassos, Center for Vaccine Development, University of Maryland School of Medicine, Berhane Beyene, Zenaw Adam, James D. Campbell, Nigisti Mulholland, Seydou S. Diarra, Tassew Kassa, Lisa Oot, Jenny Sequeira, Mardi Reymann, William C. Blackwelder, Marcela F. Pasetti, Samba O. Sow, Robert Steinglass, Amha Kebede, and Myron M. Levine.
Improving maternal and child health remains a top priority in Nigeria’s Bauchi State in the northeastern region where the maternal mortality ratio (MMR) and infant mortality rate (IMR)are as high as 1540 per 100,000 live births and 78 per 1,000 live births respectively. This study used the framework of the continuum of maternal and child care to evaluate the impact of interventions in Bauchi State focused on improved maternal and child health, and to ascertain progress towards the achievement of Millennium Development Goals (MDGs) 4 and 5.
Women residents in the households were interviewed about their own health and that of their children. Estimated LGA coverage of maternal and child health indicators were aggregated across the State. These values were then compared to the national figures, and the differences from 2012 to 2014 were calculated. For several of the indicators, a modest improvement from baseline was found. However, the indicators in the continuum of care neither reached the national average nor attained the 90% globally recommended coverage level.
Intensive scale-up of programs and interventions is needed in Bauchi State, Northern Nigeria, to accelerate, consolidate and sustain the modest but significant achievements in the continuum of care, if MDGs 4 and 5 are to be achieved by the end of 2015. The intentional focus of LGAs as the unit of intervention ought to be considered a condition precedent for future investments. Priority should be given to the re-allocating resources to program areas and regions where coverage has been low. Finally, systematic considerations need to be given to the design of strategies that address the demand for health services.
Reducing the burden of diarrhea among children under five years old: Lessons learned from oral rehydration therapy corner program implementation in Northern Nigeria in Journal of Health, Population, and Nutrition
Oral rehydration theraphy (ORT) corners were introduced at health facilities in the Northern Nigerian states of Bauchi and Sokoto to treat sick children and equip caregivers with skills in case management of diarrhea and diarrhea prevention. Researches from the Targeted States High Impact (TSHIP) project, including Olugbenga Oguntunde, Amos Paul Bassi, Mohammed Auwal Ibrahim, Saba'atu Danladi, William Sambisa, and Nurudeen Lawal, studied the effect of facility-based ORT corners on caregivers' knowledge and case management skills and examined whether ORT activities were conducted according to protocol.
Study results showed that ORT corner users were more knowledgeable in diarrhea prevention and management and demonstrated better skills for managing diarrhea than ORT corner non-users. The research methods, findings, and recommendations have been published in the May 2015 issue of the Journal of Health, Population, and Nutrition.
Iron+folic acid distribution and consumption through antenatal care: identifying barriers across countries in Journal of Public Health Nutrition
The prevalence of maternal anemia remains unacceptably high in developing countries. At the same time, the percentage of women who consume one or more Fe+folic acid (IFA) tablets during pregnancy remains persistently low. The objective of this study, conducted by researchers from the SPRING project, including JSI's Alexis D'Agostino, was to identify where, within antenatal care (ANC) programs, pregnant women falter in obtaining and consuming an ideal minimum of 180 IFA tablets.
View the abstract and download the full article at the Journal of Public Health Nutrition
The gas cylinder, the motorcycle and the village health team member: a proof-of-concept study for the use of the Microsystems Quality Improvement Approach to strengthen the routine immunization system in Uganda in Implementation Science, Volume 10
The Africa Routine Immunization Systems Essentials-System Innovation (ARISE-SI) initiative assessed the application of the Microsystems Quality Improvement Approach for generating local solutions to strengthen RI systems in Masaka District, Uganda. Assessment was made through quantitative and qualitative methods and found that barriers to routine immunization, including lack of back up gas cylinders at facilities, inadequate transportation, and underutilized village health teams, were successfully addressed through the Microsystems Quality Improvement Approach. JSI's Lea Ayers LaFave co-authored the article based on the ARISE-SI assessment with researchers from the Darmouth Institute for Health Policy and Clinical Practice, Dartmouth's Geisel School of Medicine, Loma Linda University School of Medicine and the Makerere University School of Public Health.
Read the full article at Implementation Science
Trends in childbirth with no one present in Nigeria between 2003 and 2013 in International Journal of Women's Health, Vol. 7
Nigeria has one of the highest maternal mortality rates in the world. Contributing to this statistic is the high percentage of births that take place at home without the presence of a skilled birth attendant. Researchers, including JSI's Bolaji Fapohunda and Nosa Orobaton, examined pooled data sets from the 2003, 2008, and 2013 Nigerian Demographic and Health Surveys to document trends in women delivering at home with no one present and identify unifying characteristics of these women.
Study results indicated that delivery with no one present declined by 30% overall between 2003 and 2013, however there was a 27% increase in births with no one present in Nigeria's North West region. Age, income, and religious practices also emerged as factors in determining the likelihood that a woman would deliver at home with no one present. Findings also suggest a stagnation in the decline of unattended births in Nigeria; researchers call for the implementation of interventions to ensure timely access to and use of skilled obstetric care to reduce maternal mortality and morbidity.
Read the full article at International Journal of Women's Health
The Effect of Access to Contraceptive Services on Injectable Use and Demand for Family Planning in Malawi in International Perspectives on Sexual and Reproductive Health
One of the most direct ways to reduce maternal mortality rates in developing countries is to address unmet need for contraception - that is, enable women who want to avoid or delay pregnancy to access modern family planning methods. Understanding the barriers to this access is therefore critical to reducing maternal mortality.
To better understand these barriers, JSI staff from the USAID | DELIVER PROJECT and members of the MEASURE Evaluation team looked at what modern mapping software and logistics data reveal about how women in Malawi respond to the availability of contraceptive services in their local environment.
Transactional Sex Among Men Who Have Sex With Men in Latin America: Economic, Sociodemographic, and Psychosocial Factors in American Journal of Public Health
Researchers, including JSI's Stewart Landers (Director of JSI Health Services, Boston) assessed factors associated with engagement in transactional sex among men who have sex with men recruited from one of the largest internet sites for men seeking social or sexual interaction with other men in Latin America. Factors were analyzed by way of multilevel regression models in 17 Latin American Countries. Research findings showed that higher country-level unemployment was associated with increased odds of transactional sex. A correlation between interpersonal or individual factors, such as self-reported HIv or sexually transmitted infection, intimate partner violence, and sexual compulsivity, and elevated odds of engagement in transactional sex was also found.
Engaging Communities With a Simple Tool to Help Increase Immunization Coverage in Global Health: Policy and Practice
The level of vaccination coverage in a given community depends on both service factors and the degree to which the public understands and trusts the immunization process. This article describes an approach that aims to raise awareness and boost demand. Developed in India, the “My Village Is My Home” (MVMH) tool, known as Uma Imunizasaun (UI) in Timor-Leste, is a poster-sized material used by volunteers and health workers to record the births and vaccination dates of every infant in a community. Introduction of the tool in 5 districts of India and in 7 initial villages in Timor-Leste allowed community leaders, volunteers, and health workers to monitor the vaccination status of every young child and guided reminder and motivational visits.
In India, pilot communities had 80% or higher coverage of identified and eligible children for all vaccines. In comparison, overall coverage in the respective districts during the same time period was much lower, at 49% to 69%. In Timor-Leste, both the number of infants identified and immunized rose substantially with use of the tool compared with the previous year. The experiences in both countries suggest that “My Village Is My Home” is a promising tool that has the potential to broaden program coverage by marshalling both community residents and health workers to track individual children's vaccinations. Three states in India have adopted the tool, and Timor-Leste had also planned to scale-up the initiative.
Glob Health Sci Pract 2015;3(1):117-125.
Mental health of youth orphaned due to AIDS in South Africa: biological and supportive links to caregivers in Vulnerable Children and Youth Studies: An International Interdisciplinary Journal for Research, Policy and Care
In South Africa, over two million children have lost at least one parent to HIV. Youth who are orphaned by the AIDS epidemic have significantly higher levels of depression, anxiety, and post-traumatic stress than non-orphaned youth, or orphans whose parents died from other causes.
Researchers, including JSI's Melissa Sharer, explored the biological and social support relationship between youth orphaned by HIV/AIDS and their caregivers to identify factors related to positive mental health outcomes. 254 orphaned youths were selected from a 2009 cross-sectional survey to examine caregiver relationships and their affect on the mental health of the youth. Download the full article for research methodology and findings.